What is the primary function of the IRB/IEC?

• A. To approve trials without review
• B. To review and evaluate the science, medical aspects, and ethics of proposed trials
• C. To manage the trial budget
• D. To recruit participants

Answer: (B)

The function of an IRB/IEC is to protect the rights, safety, and welfare of research participants by reviewing and evaluating the science, medical aspects, and ethics of proposed trials. This review determines whether the potential risks are minimized and reasonable in relation to anticipated benefits, whether the informed consent process is appropriate and adequate, and whether participants are selected fairly. The IRB/IEC also considers ongoing protections, such as continuing review and safety monitoring, and ensures safeguards for confidentiality and vulnerable populations. This is why that option is the best fit. The other roles—approving trials without review, managing the budget, or recruiting participants—do not reflect the primary function of the IRB/IEC.