What is the function of an endpoint assessment/adjudication committee?

• A. They recruit participants.
• B. Such committees review endpoints reported by investigators to determine if they meet protocol-specified criteria, typically while being blinded to assigned treatments.
• C. They handle data entry.
• D. They manage monitoring visits.

Answer: (B)

Endpoint assessment/adjudication committees exist to provide an independent, blinded review of trial endpoints. Their job is to examine endpoint data reported by investigators and decide whether each endpoint meets the protocol's predefined criteria for occurrence. Keeping the review blinded to treatment assignment helps prevent bias in how endpoints are classified. They don’t recruit participants, handle data entry, or oversee monitoring visits; those duties lie with investigators, data managers, and monitors.