Reducing unnecessary complexity primarily improves which two aspects?

• A. Feasibility and participant safety.
• B. Recruitment speed only.
• C. Data volume only.
• D. Regulatory compliance only.

Answer: (A)

Reducing unnecessary complexity improves feasibility and participant safety. When a protocol is overly intricate, sites face more challenges implementing it, which can slow setup, hinder recruitment, increase deviations, elevate costs, and threaten timely completion. Streamlining procedures, visits, and data requirements makes the trial easier to run in real-world settings, supports smoother training and monitoring, and enhances the likelihood of finishing the study within resources and timelines. At the same time, a simpler design reduces participant burden and the potential for procedural errors, which helps ensure safety monitoring is performed consistently and adverse events are captured accurately. While other benefits may touch on recruitment speed, data volume, or regulatory tasks, the two most directly improved aspects by simplicity are practical feasibility and participant safety.